Gene information
Official symbol F2R
Official full name coagulation factor II thrombin receptor
Gene type protein-coding gene
Chromosome5q13.3
Alias symbolTR; CF2R; PAR1; PAR-1
Gene familyF2R receptors
Resources
Entrez Gene 2149
HGNC HGNC:3537
Ensembl ENSG00000181104
Vega OTTHUMG00000131299
UCSC uc003ken.5
GO terms: 126 records
GO Description Category LogP Number of genes Detail
GO:0001653 peptide receptor activity GO Molecular Functions -6.43798881 12 More
GO:0001977 renal system process involved in regulation of blood volume GO Biological Processes -6.20743023 5 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003014 renal system process GO Biological Processes -10.4348518 24 More
GO:0003018 vascular process in circulatory system GO Biological Processes -47.1670528 52 More
GO:0003071 renal system process involved in regulation of systemic arterial blood pressure GO Biological Processes -9.64792348 8 More
GO:0003073 regulation of systemic arterial blood pressure GO Biological Processes -22.2238525 34 More
GO:0003093 regulation of glomerular filtration GO Biological Processes -3.72958795 3 More
GO:0003105 negative regulation of glomerular filtration GO Biological Processes -5.18367662 3 More
GO:0005769 early endosome GO Cellular Components -6.25251045 19 More
GO:0005770 late endosome GO Cellular Components -2.28850711 22 More
GO:0005901 caveola GO Cellular Components -18.8033423 19 More
GO:0006816 calcium ion transport GO Biological Processes -5.55009887 27 More
GO:0006937 regulation of muscle contraction GO Biological Processes -20.8046481 43 More
GO:0006940 regulation of smooth muscle contraction GO Biological Processes -12.9613663 21 More
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO Biological Processes -11.6592522 24 More
GO:0007204 positive regulation of cytosolic calcium ion concentration GO Biological Processes -15.6883547 39 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008217 regulation of blood pressure GO Biological Processes -35.2019435 60 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0008528 G protein-coupled peptide receptor activity GO Molecular Functions -6.62401664 12 More
GO:0010712 regulation of collagen metabolic process GO Biological Processes -14.4967625 19 More
GO:0010950 positive regulation of endopeptidase activity GO Biological Processes -13.2452311 34 More
GO:0010952 positive regulation of peptidase activity GO Biological Processes -14.1524623 37 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -15.9250248 30 More
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -18.2876323 28 More
GO:0019229 regulation of vasoconstriction GO Biological Processes -25.9471687 22 More
GO:0030001 metal ion transport GO Biological Processes -7.54203733 26 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0031644 regulation of nervous system process GO Biological Processes -8.22607591 24 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032651 regulation of interleukin-1 beta production GO Biological Processes -19.7300517 34 More
GO:0032652 regulation of interleukin-1 production GO Biological Processes -24.2088254 41 More
GO:0032675 regulation of interleukin-6 production GO Biological Processes -28.2553997 51 More
GO:0032677 regulation of interleukin-8 production GO Biological Processes -20.0046302 33 More
GO:0032755 positive regulation of interleukin-6 production GO Biological Processes -18.6559032 31 More
GO:0032965 regulation of collagen biosynthetic process GO Biological Processes -13.1192794 17 More
GO:0033363 secretory granule organization GO Biological Processes -1.60173867 3 More
GO:0034330 cell junction organization GO Biological Processes -7.96624809 49 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0034767 positive regulation of ion transmembrane transport GO Biological Processes -11.2867591 18 More
GO:0035023 regulation of Rho protein signal transduction GO Biological Processes -3.55619697 12 More
GO:0035025 positive regulation of Rho protein signal transduction GO Biological Processes -2.57451150 6 More
GO:0035150 regulation of tube size GO Biological Processes -44.5138102 41 More
GO:0035296 regulation of tube diameter GO Biological Processes -44.6572858 41 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0043087 regulation of GTPase activity GO Biological Processes -2.19988031 26 More
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO Biological Processes -8.71585030 18 More
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO Biological Processes -8.04470175 15 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043270 positive regulation of ion transport GO Biological Processes -23.5832054 34 More
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -14.7594418 39 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043523 regulation of neuron apoptotic process GO Biological Processes -14.5388618 39 More
GO:0043524 negative regulation of neuron apoptotic process GO Biological Processes -11.6647584 29 More
GO:0043547 positive regulation of GTPase activity GO Biological Processes -1.94334853 20 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044060 regulation of endocrine process GO Biological Processes -7.84992769 12 More
GO:0044853 plasma membrane raft GO Cellular Components -18.4542052 33 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045211 postsynaptic membrane GO Cellular Components -5.83105498 30 More
GO:0045216 cell-cell junction organization GO Biological Processes -2.57190963 16 More
GO:0045907 positive regulation of vasoconstriction GO Biological Processes -14.7401025 12 More
GO:0045933 positive regulation of muscle contraction GO Biological Processes -10.2635447 16 More
GO:0045987 positive regulation of smooth muscle contraction GO Biological Processes -5.46031079 9 More
GO:0046425 regulation of receptor signaling pathway via JAK-STAT GO Biological Processes -10.5317026 20 More
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT GO Biological Processes -10.8890337 15 More
GO:0046578 regulation of Ras protein signal transduction GO Biological Processes -3.44587232 19 More
GO:0046579 positive regulation of Ras protein signal transduction GO Biological Processes -5.05172294 12 More
GO:0048771 tissue remodeling GO Biological Processes -15.8777137 28 More
GO:0048871 multicellular organismal homeostasis GO Biological Processes -14.5562171 53 More
GO:0048873 homeostasis of number of cells within a tissue GO Biological Processes -5.73116566 9 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0050709 negative regulation of protein secretion GO Biological Processes -12.5236372 21 More
GO:0050808 synapse organization GO Biological Processes -6.17744712 32 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051048 negative regulation of secretion GO Biological Processes -20.2278199 42 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051057 positive regulation of small GTPase mediated signal transduction GO Biological Processes -4.49369376 12 More
GO:0051209 release of sequestered calcium ion into cytosol GO Biological Processes -4.43542328 10 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051224 negative regulation of protein transport GO Biological Processes -11.0190941 26 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051279 regulation of release of sequestered calcium ion into cytosol GO Biological Processes -5.25087734 14 More
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO Biological Processes -3.97244449 5 More
GO:0051282 regulation of sequestering of calcium ion GO Biological Processes -7.93009971 22 More
GO:0051283 negative regulation of sequestering of calcium ion GO Biological Processes -4.35719226 10 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO Biological Processes -4.39154198 8 More
GO:0051924 regulation of calcium ion transport GO Biological Processes -18.2498286 49 More
GO:0060155 platelet dense granule organization GO Biological Processes -2.55598907 3 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0070588 calcium ion transmembrane transport GO Biological Processes -2.54626507 17 More
GO:0090066 regulation of anatomical structure size GO Biological Processes -32.7608623 52 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0097553 calcium ion transmembrane import into cytosol GO Biological Processes -4.27502414 13 More
GO:0097746 blood vessel diameter maintenance GO Biological Processes -44.6572858 41 More
GO:0098655 cation transmembrane transport GO Biological Processes -3.98966777 20 More
GO:0098660 inorganic ion transmembrane transport GO Biological Processes -4.47276690 21 More
GO:0098662 inorganic cation transmembrane transport GO Biological Processes -4.65654157 20 More
GO:0098794 postsynapse GO Cellular Components -5.82876983 23 More
GO:0098801 regulation of renal system process GO Biological Processes -10.5008143 14 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0099536 synaptic signaling GO Biological Processes -6.00976162 42 More
GO:0099537 trans-synaptic signaling GO Biological Processes -5.17038357 38 More
GO:1901215 negative regulation of neuron death GO Biological Processes -19.0527525 45 More
GO:1903169 regulation of calcium ion transmembrane transport GO Biological Processes -8.80532519 28 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903531 negative regulation of secretion by cell GO Biological Processes -17.4034654 36 More
GO:1903828 negative regulation of protein localization GO Biological Processes -8.86943289 30 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
GO:1904064 positive regulation of cation transmembrane transport GO Biological Processes -10.8655330 17 More
GO:1904427 positive regulation of calcium ion transmembrane transport GO Biological Processes -4.11465146 13 More
GO:1904892 regulation of receptor signaling pathway via STAT GO Biological Processes -12.9980471 24 More
GO:1904894 positive regulation of receptor signaling pathway via STAT GO Biological Processes -11.2917234 16 More
GO:1904950 negative regulation of establishment of protein localization GO Biological Processes -11.4813166 27 More
GO:2000116 regulation of cysteine-type endopeptidase activity GO Biological Processes -14.4496812 41 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 7 records
KEGG Description Category LogP Number of genes Detail
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa04024 cAMP signaling pathway KEGG Pathway -7.78464854 30 More
hsa04072 Phospholipase D signaling pathway KEGG Pathway -3.77257282 17 More
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04611 Platelet activation KEGG Pathway -14.0379587 18 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
Drug-Gene interaction
view
Related drugs: 16 records
Drug name Interaction type Source PMID View
alcohol NCI 16930224 view
argatroban NCI 10611442 view
aspirin NCI 15381054 view
atopaxar antagonist ChemblInteractionsTTD view
atropine NCI 15345469 view
bleomycin NCI 15855637 view
dalteparin NCI 12632026 view
lepirudin NCI 16038707 view
morphine NCI 12373743 view
rigosertib sodium inhibitor ChemblInteractions view
rusalatide TdgClinicalTrial view
thalidomide NCI 14995997 view
thrombin NCI 15559761152804471150451810027305153836301270703311841573153863851469910216505172 view
vorapaxar antagonist TdgClinicalTrialTTD 19715408 view
vorapaxar sulfate antagonist ChemblInteractions view
wortmannin NCI 1031886075594108955143 view
Related studies: 5 records
Molecular factor Omics type Application Objective MI type Reference
NM_001992.5:c.[-1738G>A;2860G>A] genomics myocardial infarction[diagnosis] myocardial infarction Gigante B et al. Thromb Haemost. 2009
NM_001992.5:c.[-1738G>A;-506GGCCGCGGGAAGC[3];2860G>A;88+693C>A;88+6876C>A;88+7096C>T;*1468T>C]*NM_000600.5:c.[-174G>C;-572G>C;324+147C>G] genomics myocardial infarction[diagnosis] myocardial infarction Gigante B et al. PLoS One. 2010
NM_001992.5:c.-1738G>A genomics myocardial infarction[diagnosis] myocardial infarction Gigante B et al. Thromb Haemost. 2009
NM_001992.5:c.2860G>A genomics myocardial infarction[diagnosis] myocardial infarction Gigante B et al. Thromb Haemost. 2009
NG_032906.1:g.21257A>T genomics ischemic cardiac events[prognosis (bad)] ST elevation myocardial infarction Zhang JH et al. Platelets. 2016
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